The film chronicles the account of elementary school teacher Anna Marchant (Milla Jovovich), who is attacked by a serial killer known only as Tearjerk Jack and survives, but is left to struggle with a neurological disorder commonly referred to as face-blindness (prosopagnosia).
Only able to recognize voices, she fights to adapt to her diagnosis and the ever-changing faces of those around her. Working with Detective Kerrest (Julian McMahon), Anna races to identify her attacker. All the while the killer is closing in, determined to eliminate this potential witness. Only Anna has seen his face – and he could be anyone.